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    This allows for shunting of T4 to the brain where it is preferentially deiodinated to T3 by type II MDI, preserving normal central nervous system development (Fisher et al, 1994).

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    T4 is rapidly converted to apparently inactive forms of the hormone has led investigators to question whether some of these T4 derivatives have unappreciated functions in activation of alternate receptors or as metabolic precursors of different active forms of the hormone.

    Based Practice of Critical Care, 2010Decrease Peripheral Conversion of T4 to T3Glucocorticoids can effectively reduce the peripheral deiodination of T4 to T3 and may be helpful in treating underlying Graves disease.

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    Xjis.nls download sp3 windows 7HPLC methods for sample analysis were also adopted for determination of deiodinase activities, taking advantage of the possibility to directly quantify substrates and products online by radiometric detector systems or subsequently quantify eluted fractions containing substrate and products, using γ counters.

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